General Information

  • ID:  hor004104
  • Uniprot ID:  B3A0K8
  • Protein name:  Pyrokinin-4
  • Gene name:  NA
  • Organism:  Pachyphasma brandbergense (Gladiator) (Heel-walker)
  • Family:  Pyrokinin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Pachyphasma (genus), Mantophasmatidae (family), Mantophasmatodea (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  AELPQGLWVRPRLG
  • Length:  14(1-14)
  • Propeptide:  AELPQGLWVRPRLG
  • Signal peptide:  NA
  • Modification:  T14 Glycine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Myoactive
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004104_AF2.pdbhor004104_ESM.pdb

Physical Information

Mass: 182394 Formula: C73H118N22O18
Absent amino acids: CDFHIKMNSTY Common amino acids: L
pI: 10.4 Basic residues: 2
Polar residues: 2 Hydrophobic residues: 6
Hydrophobicity: -25 Boman Index: -1737
Half-Life: 4.4 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 111.43
Instability Index: 5602.14 Extinction Coefficient cystines: 5500
Absorbance 280nm: 423.08

Literature

  • PubMed ID:  22508719
  • Title:  Peptidomics-based phylogeny and biogeography of Mantophasmatodea (Hexapoda).